Methylation is a crucial biochemical process that affects nearly every system in the body, influencing detoxification, neurotransmitter production, cardiovascular health, and DNA expression. For individuals with an MTHFR (methylenetetrahydrofolate reductase) mutation, optimizing methylation becomes particularly important, as genetic variants can impair the body's ability to process folate efficiently. While taking methylfolate is a great first step, additional support may be necessary to enhance overall methylation function and prevent downstream effects on health.